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These polymorphic variants usually have decreased enzyme activity and are often reported with reduced enzyme stability as well as disruptions in protein folding (13)
Diabetologia 61:24992506 Newsholme P, Keane KN, Carlessi R, Cruzat V (2019) Oxidative stress pathways in pancreatic -cells and insulin-sensitive cells and tissues: importance to cell metabolism, function, and dysfunction
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